You can now watch the video replay of the recent National Academies of Sciences, Engineering, and Medicine workshop on “long haul” illnesses such as long COVID, persistent Lyme disease, multiple sclerosis and ME/CFS.

Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: A Workshop to Examine Common, Overlapping Clinical and Biological Factors was a two-day event, bringing together researchers, health officials, and patient advocates.

The recordings are broken up into 11 segments. See below each one for the list of who is speaking during that segment.

Day 1

1-Day 1 – Welcome Remarks from The National Academies on Vimeo.

Welcome
Peter Daszak, EcoHealth Alliance
Chair, Forum on Microbial Threats
John Krystal, Yale University
Co-Chair, Forum on Neuroscience and Nervous System Disorders

Introduction and workshop overview
Tim Coetzee, National Multiple Sclerosis Society
Workshop co-chair

Sponsor perspectives
Lyle Petersen, US Centers for Disease Control and Prevention
Ben Nemser, Steven & Alexandra Cohen Foundation

2-Day 1 – Session 1 from The National Academies on Vimeo.

Introduction to infection-associated chronic illnesses

Moderator: Rafael Obregon, UNICEF

Keynote
Tim Henrich, University of California, San Francisco
Introduction and a historical perspective
Anthony Komaroff, Harvard Medical School; Brigham and Women’s Hospital

Stakeholder perspectives
Joseph Breen, National Institutes of Health (NIH) RECOVER
Harlan Krumholz, Yale School of Medicine
Hannah Davis, Patient-Led Research Collaborative
Meghan O’Rourke, Yale University
Author of The Invisible Kingdom: Reimagining Chronic lllness

3-Day 1 – Session 2 from The National Academies on Vimeo.

Common mechanistic factors of infection-associated chronic illnesses.

Host mediated factors (part 1)

Moderator: Peter Rowe, Johns Hopkins University

Immune Dysfunction
Post COVID syndrome and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): evidence for a role of autoantibodies and endothelial dysfunction and development of targeted therapies
Carmen Scheibenbogen, Charité University

Viral reactivation
Michael Peluso, University of California, San Francisco

Autonomic Dysfunction

Overview of orthostatic intolerance: risk factors and treatments
Satish Raj, University of Calgary

Common underlying mechanisms of chronic illness: Lessons from postural orthostatic tachycardia syndrome (POTS), ME/CFS, and Long COVID
Mitchell Miglis, Stanford University

Q & A

4-Day 1 – Session 3 from The National Academies on Vimeo.

Common mechanistic factors of infection-associated chronic illnesses.

Host mediated factors (part 2)

Moderator: Brian Fallon, Columbia University

Impact of inflammation on the brain: significance for chronic illnesses
Andrew Miller, Emory University

Role of the microbiome in ME/CFS
Julia Oh, The Jackson Laboratory

Pathogen mediated factors and pathogen persistence

Viral persistence and development of chronic illness: lessons from Epstein-Barr virus (EBV)
Bill Robinson, Stanford University

Pathogen distribution and persistence: learnings from SARS-CoV-2
Dan Chertow, NIH

Modeling pathogen persistence: lessons from animal studies
Monica Embers, Tulane University

Q&A

5-Day 1 – Session 4 from The National Academies on Vimeo.

Session 4: Future opportunities and research priorities in diagnostics

Moderator: Avindra Nath, National Institute of Neurological Disorders and Stroke (NINDS), NIH

Biomarkers for Lyme disease and post-treatment Lyme
John Aucott, Johns Hopkins University

Biomarkers for EBV and associations with multiple sclerosis (MS)
Alberto Ascherio, Harvard T.H Chan School of Public Health

Microclots as a common indicator of chronic disease
Resia Pretorius, Stellenbosch University

Next-generation and metagenomic sequencing
Charles Chiu, University of California, San Francisco

Synthesis and adjourn
Amy Proal, PolyBio Research Foundation

DAY 2

1-Day 2 – Welcome Remarks from The National Academies on Vimeo.

Welcome remarks, review of day 1

Welcome and introduction
Tim Endy, Coalition for Epidemic Preparedness Innovations (CEPI)
Workshop co-chair

Keynote
Hilary Marston
Chief Medical Officer, U.S. Food and Drug Administratio

2-Day 2 – Session 5 from The National Academies on Vimeo.

Session 5: Patient driven research panel

Moderator: Liz Horn, Lyme Disease Biobank

Panel:
Lisa McCorkell, Patient-Led Research Collaborative
Oved Amitay, Solve ME/CFS
Lorraine Johnson, MyLymeData
Liz Horn, Lyme Disease Biobank

Q & A

3-Day 2 – Session 6 from The National Academies on Vimeo.

Session 6: Research innovation and required infrastructures

Moderator: Tim Endy, CEPI

Diagnostic journeys of Long COVID patients
Linda Geng, Stanford University

Ultrasensitive diagnostic assays: examples with SARS-CoV-2 and Long COVID
David Walt, Harvard University

Translating infection-associated chronic illnesses research into the clinic in drug repurposing
Steven Deeks, University of California, San Francisco

Treatment approaches to post-treatment Lyme disease and a new clinical trials network
Brian Fallon, Columbia University

Q & A

4-Day 2 – Session 7 from The National Academies on Vimeo.

Session 7: Future opportunities and research priorities in therapeutics

Moderator: Tim Coetzee, National Multiple Sclerosis Society

Development of Oral Antiviral for COVID-19
Ravi Shankar Singh, Pfizer

Development of antivirals and combination therapies for infection-associated chronic illnesses
Sara Cherry, University of Pennsylvania

Clinical trials for multisystem inflammatory syndrome in children (MIS-C) and Long COVID
Alessio Fasano, Harvard University

Long Lyme: opportunities for prevention and treatment
Kim Lewis, Northeastern University

Clinical care for patients of various infection-associated chronic illnesses
David Putrino, Mount Sinai H

Q & A

5-Day 2 – Session 8 and Synthesis and Close from The National Academies on Vimeo.

Session 8: Developing a shared research agenda: challenges and opportunities

Moderators:
Avindra Nath, NINDS, NIH
Amy Proal, PolyBio Research Foundation
Lorraine Johnson, MyLymeData
Peter Rowe, Johns Hopkins University

Q&A

Synthesis and close
Tim Endy, CEPI
Tim Coetzee, National Multiple Sclerosis Society
    Workshop co-chairs